MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
作者: Liv B. GansmoMerete BjørnslettMari Kyllesø HalleHelga B. SalvesenPål RomundstadKristian HveemLars VattenAnne DørumPer E. LønningStian Knappskog
作者单位: 1University of Bergen, Haukeland University Hospiltal
2Haukeland University Hospital
3Oslo University Hospital Radium Hospitalet
4University of Oslo
5University of Bergen
6Norwegian University of Science and Technology
7Oslo University Hospital, Norwegian Radium Hospital
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-017-3094-y
关键词: MDM2Del1518Cancer riskOvarian cancerEndometrial cancer
英文摘要: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an increased risk of colon cancer. In this study we assessed the impact of MDM2 del1518 on risk of ovarian and endometrial cancer.
原始语种摘要: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an increased risk of colon cancer. In this study we assessed the impact of MDM2 del1518 on risk of ovarian and endometrial cancer.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • endometrial 子宫内膜的
  • ovarian 卵巢的
  • promoter 催化剂
  • cancer 癌症
  • impact 冲击碰撞
  • variant 变体
  • polymorphism 多晶形
  • previously 以前
  • colon 结肠
  • linkage 连接