Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents
作者: Woo Seok YangSeung-Gu YeoSungjae YangKyung-Hee KimByong Chul YooJae Youl Cho
作者单位: 1Sungkyunkwan University
2Soonchunhyang University College of Medicine, Soonchunhyang University Hospital
3National Cancer Center
刊名: Amino Acids, 2017, Vol.49 (9), pp.1469-1485
来源数据库: Springer Journal
DOI: 10.1007/s00726-017-2454-x
关键词: ICMT inhibitorCancerMethylationCysmethynilRas
英文摘要: Among the enzymes involved in the post-translational modification of Ras, isoprenyl carboxyl methyltransferase (ICMT) has been explored by a number of researchers as a significant enzyme controlling the activation of Ras. Indeed, inhibition of ICMT exhibited promising anti-cancer activity against various cancer cell lines. This paper reviews patents and research articles published between 2009 and 2016 that reported inhibitors of ICMT as potential chemotherapeutic agents targeting Ras-induced growth factor signaling. Since ICMT inhibitors can modulate Ras signaling pathway, it might be possible to develop a new class of anti-cancer drugs targeting Ras-related cancers. Researchers have discovered indole-based small-molecular ICMT inhibitors through high-throughput screening. Researchers at...
原始语种摘要: Among the enzymes involved in the post-translational modification of Ras, isoprenyl carboxyl methyltransferase (ICMT) has been explored by a number of researchers as a significant enzyme controlling the activation of Ras. Indeed, inhibition of ICMT exhibited promising anti-cancer activity against various cancer cell lines. This paper reviews patents and research articles published between 2009 and 2016 that reported inhibitors of ICMT as potential chemotherapeutic agents targeting Ras-induced growth factor signaling. Since ICMT inhibitors can modulate Ras signaling pathway, it might be possible to develop a new class of anti-cancer drugs targeting Ras-related cancers. Researchers have discovered indole-based small-molecular ICMT inhibitors through high-throughput screening. Researchers at...
全文获取路径: Springer  (合作)
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影响因子:3.914 (2012)

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关键词翻译
关键词翻译
  • recent 近来的
  • carboxyl 羧基
  • targeting 导向目标
  • functional 功能的
  • inhibitor 抑制剂
  • translational 平移的
  • related 有关的
  • facilitate 简化
  • targeted 对准目标的
  • screening 筛分