How driving endonuclease genes can be used to combat pests and disease vectors
作者: H. Charles J. GodfrayAce NorthAustin Burt
作者单位: 1University of Oxford
2Imperial College London
刊名: BMC Biology, 2017, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12915-017-0420-4
关键词: Gene driveGene editingEndonucleasesCRISPR-Cas9Vector controlPest controlMosquitoes
英文摘要: Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the homologue as a template the DEG heterozygote is converted to a homozygote. Some DEGs occur naturally while several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particularly flexible. There is great interest in using driving endonuclease genes to impose a genetic load on insects that vector diseases or are economic pests to reduce their population density, or to introduce a beneficial gene such as one that might interrupt disease transmission. This paper...
原始语种摘要: Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the homologue as a template the DEG heterozygote is converted to a homozygote. Some DEGs occur naturally while several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particularly flexible. There is great interest in using driving endonuclease genes to impose a genetic load on insects that vector diseases or are economic pests to reduce their population density, or to introduce a beneficial gene such as one that might interrupt disease transmission. This paper...
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来源刊物:
影响因子:6.531 (2012)

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关键词翻译
关键词翻译
  • endonuclease 核酸内切酶
  • genetic 遗传的
  • homologous 同结构型的
  • inserted 嵌入的
  • driving 传动的
  • population 母体
  • several 各自
  • naturally 当然
  • heterozygote 异型接合体
  • likelihood 似然