Photothermal/pH Dual-Responsive Drug Delivery System of Amino-Terminated HBP-Modified rGO and the Chemo-Photothermal Therapy on Tumor Cells
作者: Wei ZhangJiamu DaiGuangyu ZhangYu ZhangSuying LiDu Nie
作者单位: 1National and Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection, Nantong University
2School of Textile and Clothing, Nantong University
刊名: Nanoscale Research Letters, 2018, Vol.13 (1), pp.1-10
来源数据库: Springer Nature Journal
DOI: 10.1186/s11671-018-2787-8
关键词: Graphene oxideHyperbranched polymerDrug deliveryDual responsiveChemo-photothermal therapy
英文摘要: Abstract(#br)In this paper, a simple method to prepare hydrophilic reduced graphene oxide (rGO) was proposed via reducing GO by amino-terminated hyperbranched polymer (NHBP), the as-prepared NrGO could present excellent dispersibility, near infrared (NIR) light absorbance, photothermal conversion ability and stability. Then, the doxorubicin hydrochloride (DOX) was conjugated with NrGO to prepare the drug-loading system, and a pH/photothermal dual-responsive drug delivery behavior was characterized. At acidic environment or under NIR laser irradiation, the drug release rate could be improved, which is beneficial to control release anti-tumor drug in tumor tissues. What is more, the in vitro cell experiments revealed that NrGO was well biocompatible, and in the tumor inhibition part,...
全文获取路径: Springer Nature  (合作)
影响因子:2.524 (2012)