Functions of pregnane X receptor in self-detoxification
作者: Liuqin HeXihong ZhouNiu HuangHuan LiTiejun LiKang YaoYanan TianChien-An Andy HuYulong Yin
作者单位: 1Chinese Academy of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock and Poultry
2University of the Chinese Academy of Sciences
3Hunan Agricultural University
4Hunan Co-Innovation Center of Animal Production Safety
5Chinese Academy of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hu
刊名: Amino Acids, 2017, Vol.49 (12), pp.1999-2007
来源数据库: Springer Journal
DOI: 10.1007/s00726-017-2435-0
关键词: PXRInflammatory responseSelf-detoxificationCYP450NF-κB
英文摘要: Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis. Notably, much experimental and clinical evidence show that PXR senses xenobiotics and triggers the detoxification response to prevent diseases such as diabetes, obesity, intestinal inflammatory diseases and liver fibrosis. In this review we summarize recent advances on remarkable metabolic and regulatory versatility of PXR, and we emphasizes its role and potential implication as an effective modulator of self-detoxification in animals and humans.
原始语种摘要: Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis. Notably, much experimental and clinical evidence show that PXR senses xenobiotics and triggers the detoxification response to prevent diseases such as diabetes, obesity, intestinal inflammatory diseases and liver fibrosis. In this review we summarize recent advances on remarkable metabolic and regulatory versatility of PXR, and we emphasizes its role and potential implication as an effective modulator of self-detoxification in animals and humans.
全文获取路径: Springer  (合作)
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影响因子:3.914 (2012)

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关键词翻译
关键词翻译
  • pregnane 孕甾烷
  • detoxification 解毒
  • receptor 接受体
  • xenobiotic 生物体内异物
  • metabolic 新陈代谢的
  • metabolism 代谢
  • regulatory 控制的
  • inflammatory 激怒的
  • cholesterol 胆甾醇
  • crucial 有决定性的