Biological/pathological functions of the CXCL12/CXCR4/CXCR7 axes in the pathogenesis of bladder cancer
作者: Alireza NazariHossein KhorramdelazadGholamhossein Hassanshahi
作者单位: 1Rafsanjan University of Medical Science
2Rafsanjan University of Medical Sciences
刊名: International Journal of Clinical Oncology, 2017, Vol.22 (6), pp.991-1000
来源数据库: Springer Nature Journal
DOI: 10.1007/s10147-017-1187-x
关键词: Bladder cancerCXCL12CXCR4CXCR7Angiogenesis
原始语种摘要: CXC chemokine ligand 12 (CXCL12) is an important member of the CXC subfamily of chemokines, and has been extensively studied in various human body organs and systems, both in physiological and clinical states. Ligation of CXCL12 to CXCR4 and CXCR7 as its receptors on peripheral immune cells gives rise to pleiotropic activities. CXCL12 itself is a highly effective chemoattractant which conservatively attracts lymphocytes and monocytes, whereas there exists no evidence to show attraction for neutrophils. CXCL12 regulates inflammation, neo-vascularization, metastasis, and tumor growth, phenomena which are all pivotally involved in cancer development and further metastasis. Generation and secretion of CXCL12 by stromal cells facilitate attraction of cancer cells, acting through its cognate...
全文获取路径: Springer Nature  (合作)
影响因子:1.727 (2012)

  • organs 男生殖器
  • bladder 膀胱
  • genesis 发生
  • required 必需
  • whereas 鉴于
  • expressed 榨出的
  • demonstrated 探明的储量
  • together 共同
  • further 进一步
  • hematopoietic 补血药