Prevalence, genetic variants and clinical implications of G-6-PD deficiency in Burkina Faso: a systematic review
作者: Abdoul Karim OuattaraPouiré YameogoLassina TraoreBirama DiarraMaléki AssihTegwindé Rébéca CompaoreDorcas Obiri-yeboahSerge Théophile SoubeigaFlorencia Wendkuuni DjigmaJacques Simpore
作者单位: 1Pietro Annigoni Biomolecular Research Center (CERBA)
2University Ouaga I Prof Joseph KI-ZERBO
3University of Cape Coast
刊名: BMC Medical Genetics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12881-017-0496-2
关键词: G-6-PD deficiencyPolymorphismHaplotypeMalariaBurkina Faso
英文摘要: It is now well-known that some antimalarials such as primaquine may induce severe hemolytic anemia in people with G-6-PD deficiency. Antimalarial drug prescriptions must, therefore take into account the patient’s G-6-PD status in malaria endemic areas such as Burkina Faso, where the prevalence of this genetic abnormality is relatively high. Although great clinical heterogeneity is observed depending on the molecular nature of the deficiency and the residual enzyme activity in the red blood cell, there is very poor data on the prevalence of G-6-PD deficiency and the distribution of involved genetic variants in Burkina Faso. In this systematic review, we present a synthesis of the various studies carried out on the G-6-PD deficiency in Burkina Faso in order to determine its prevalence,...
原始语种摘要: It is now well-known that some antimalarials such as primaquine may induce severe hemolytic anemia in people with G-6-PD deficiency. Antimalarial drug prescriptions must, therefore take into account the patient’s G-6-PD status in malaria endemic areas such as Burkina Faso, where the prevalence of this genetic abnormality is relatively high. Although great clinical heterogeneity is observed depending on the molecular nature of the deficiency and the residual enzyme activity in the red blood cell, there is very poor data on the prevalence of G-6-PD deficiency and the distribution of involved genetic variants in Burkina Faso. In this systematic review, we present a synthesis of the various studies carried out on the G-6-PD deficiency in Burkina Faso in order to determine its prevalence,...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.536 (2012)

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关键词翻译
关键词翻译
  • genetic 遗传的
  • systematic 有系统的
  • deficiency 不足
  • observed 观察到的
  • involved 涉及
  • malaria 疟疾
  • screening 筛分
  • primaquine 伯氨喹
  • clinical 临床的
  • vulnerable 要害