PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models
作者: Ymera PignochinoFederica CapozziLorenzo D’AmbrosioCarmine Dell’AglioMarco BasiricòMarta CantaAnnalisa LorenzatoFrancesca Vignolo LutatiSandra AlibertiErica PalesandroPaola BocconeDanilo GaliziaSara MianoGiulia ChiabottoLucia NapioneLoretta GammaitoniDario SangioloMaria Serena BenassiBarbara PasiniGiovanna ChiorinoMassimo AgliettaGiovanni Grignani
作者单位: 1Candiolo Cancer Institute - FPO, IRCCS
2University of Torino Medical School
3 Candiolo Cancer Institute - FPO, IRCCS
4Candiolo Cancer Institute – FPO, IRCCS
5University of Torino
6Politecnico di Torino
7Can
刊名: Molecular Cancer, 2017, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12943-017-0652-5
关键词: Predictive biomarkersPARP1 inhibitorsDNA-damaging agentsTrabectedinOlaparibBone and soft tissue sarcomasDrug synergism
英文摘要: Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action. It binds to minor groove of DNA inducing single- and double-strand-breaks. These kinds of damage lead to the activation of PARP1, a first-line enzyme in DNA-damage response pathways. We hypothesized that PARP1 targeting could perpetuate trabectedin-induced DNA damage in tumor cells leading finally to cell death.
原始语种摘要: Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action. It binds to minor groove of DNA inducing single- and double-strand-breaks. These kinds of damage lead to the activation of PARP1, a first-line enzyme in DNA-damage response pathways. We hypothesized that PARP1 targeting could perpetuate trabectedin-induced DNA damage in tumor cells leading finally to cell death.
全文获取路径: Springer  (合作)
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影响因子:5.134 (2012)

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关键词翻译
关键词翻译
  • antitumor 抗癌的
  • preclinical 临证前期的
  • sarcoma 肉瘤
  • synergism 协同酌
  • damaging 破坏性的
  • targeting 导向目标
  • expression 表示
  • activity 活度
  • synergistic 协同的
  • strand 海滨