Differential reduction of reactive oxygen species by human tissue-specific mesenchymal stem cells from different donors under oxidative stress
作者: Swati PaliwalAnupama KakkarRinkey SharmaBalram AiranSujata Mohanty
作者单位: 1All India Institute of Medical Sciences
刊名: Journal of Biosciences, 2017, Vol.42 (3), pp.373-382
来源数据库: Springer Journal
DOI: 10.1007/s12038-017-9691-8
关键词: Oxidative stressReactive oxygen speciesTissue-specific mesenchymal stem cells
英文摘要: Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of various diseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinely used in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions. Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not been reported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reduction abilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocytes were treated with Antimycin A (AMA) to induce oxidative...
原始语种摘要: Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of various diseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinely used in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions. Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not been reported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reduction abilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocytes were treated with Antimycin A (AMA) to induce oxidative...
全文获取路径: Springer  (合作)
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影响因子:1.759 (2012)

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关键词翻译
关键词翻译
  • stress 应力
  • oxidative 氧化的
  • cells 麻风细胞
  • mesenchymal 间叶细胞的
  • tissue 组织
  • specific 
  • oxygen 
  • damage 损伤
  • different 不相同的
  • regenerative 再生放大