Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis prediction in patients with non-small-cell lung cancer
作者: S. LiQ. ChenH. LiY. WuJ. FengY. Yan
作者单位: 1Zhujiang Hospital of Southern Medical University
刊名: Clinical and Translational Oncology, 2017, Vol.19 (9), pp.1147-1153
来源数据库: Springer Journal
DOI: 10.1007/s12094-017-1652-z
关键词: NSCLCCirculating tumor cells (CTCs)Epithelial–mesenchymal transition (EMT)OCT4
英文摘要: Circulating tumor cells (CTCs) with epithelial-to-mesenchymal transition (EMT) phenotypes might be related to tumor progression while OCT4 expression is involved in tumor metastasis and poor prognosis. But the possible clinical significance of EMT phenotypes of CTCs from non-small-cell lung cancer (NSCLC) patients has still to be demonstrated. Furthermore, none has been investigated the expression of OCT4 in CTCs. We therefore identified the EMT phenotype-based subsets of CTCs and determined the OCT4 expression status of CTCs in NSCLC patients, to explore their possible clinical relevance.
原始语种摘要: Circulating tumor cells (CTCs) with epithelial-to-mesenchymal transition (EMT) phenotypes might be related to tumor progression while OCT4 expression is involved in tumor metastasis and poor prognosis. But the possible clinical significance of EMT phenotypes of CTCs from non-small-cell lung cancer (NSCLC) patients has still to be demonstrated. Furthermore, none has been investigated the expression of OCT4 in CTCs. We therefore identified the EMT phenotype-based subsets of CTCs and determined the OCT4 expression status of CTCs in NSCLC patients, to explore their possible clinical relevance.
全文获取路径: Springer  (合作)
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影响因子:1.276 (2012)

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关键词翻译
关键词翻译
  • prognosis 预报
  • expression 表示
  • tumor 肿胀
  • mRNA m核糖核酸
  • EMT EMergency Treatment
  • cancer 癌症
  • mesenchymal 间叶细胞的
  • cells 麻风细胞
  • transition 转移
  • metastasis 同质蜕变