Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults
作者: J. CoulsonL. BagleyY. BarnouinS. BradburnG. Butler-BrowneH. GapeyevaJ.-Y. HogrelT. Maden-WilkinsonA. B. MaierC. MeskersC. MurgatroydM. NariciM. PääsukeL. SassanoS. SipiläN. AL-ShantiL. StenrothD. A. JonesJ. S. McPhee
作者单位: 1Manchester Metropolitan University
2Baylor College of Medicine
3Institut de Myologie, GH Pitié-Salpêtrière
4Institute of Sport Sciences and Physiotherapy, University of Tartu
5Sheffield Hallam University
6Vrij University
7University of Melbourne
8VU University Medical Center
9University of Nottingham
10Unilever Discover
11University of Jyväskylä
12University of Eastern Finland
刊名: Osteoporosis International, 2017, Vol.28 (9), pp.2683-2689
来源数据库: Springer Journal
DOI: 10.1007/s00198-017-4104-2
关键词: DKK1MYOAGEOsteoporosisOsteoprotegerinSclerostin
英文摘要: Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.
原始语种摘要: Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.
全文获取路径: Springer  (合作)
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影响因子:4.039 (2012)

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关键词翻译
关键词翻译
  • positively 断然
  • higher 
  • mineral 矿物
  • density 密度
  • older 
  • whole 全部的
  • young 年轻的
  • associated 相关的
  • average 平均
  • osteocalcin 骨钙素