Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study
作者: Xiang DingQiukui HaoMing YangTie ChenShanping ChenJirong YueSean X. LengBirong Dong
作者单位: 1Sichuan University
2Shenzhen University
3Johns Hopkins University School of Medicine
刊名: BMC Medical Genetics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12881-017-0446-z
关键词: Ataxia telangiectasia mutatedRs189037Single nucleoside polymorphismType 2 diabetes mellitusCoronary artery disease
英文摘要: Recent evidence indicates that ataxia telangiectasia mutated (ATM) is a cytoplasmic protein that involves in insulin signaling pathways. When ATM gene is mutated, this event appears to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Up to date, little information about the relationship between ATM gene polymorphism and T2DM is available. This study aimed to explore potential association between a genetic variant [single nucleotide polymorphism (SNP), i.e. rs189037C > T] in the ATM promoter region and T2DM in older adults in China.
原始语种摘要: Recent evidence indicates that ataxia telangiectasia mutated (ATM) is a cytoplasmic protein that involves in insulin signaling pathways. When ATM gene is mutated, this event appears to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Up to date, little information about the relationship between ATM gene polymorphism and T2DM is available. This study aimed to explore potential association between a genetic variant [single nucleotide polymorphism (SNP), i.e. rs189037C > T] in the ATM promoter region and T2DM in older adults in China.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.536 (2012)

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关键词翻译
关键词翻译
  • region 地域
  • promoter 催化剂
  • ATM Asynchronous Transmission Mode
  • nucleotide 核苷酸
  • polymorphism 多晶形
  • available 可供应的
  • cytoplasmic 细胞质的
  • genetic 遗传的
  • older 
  • China 中国