Identification of trunk mutations in gastric carcinoma: a case study
作者: Zhan ZhouShanshan WuJun LaiYuan ShiChixiao QiuZhe ChenYufeng WangXun GuJie ZhouShuqing Chen
作者单位: 1Zhejiang University
2Zhejiang Hospital of Traditional Chinese Medicine
3University of Texas at San Antonio
4Iowa State University
5Zhejiang California International NanoSystems Institute
刊名: BMC Medical Genomics, 2017, Vol.10 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12920-017-0285-y
关键词: Intratumor heterogeneityGastric carcinomaMultiregional samplingCancer somatic mutationCancer evolution
英文摘要: Intratumor heterogeneity (ITH) poses an urgent challenge for cancer precision medicine because it can cause drug resistance against cancer target therapy and immunotherapy. The search for trunk mutations that are present in all cancer cells is therefore critical for each patient.
原始语种摘要: Intratumor heterogeneity (ITH) poses an urgent challenge for cancer precision medicine because it can cause drug resistance against cancer target therapy and immunotherapy. The search for trunk mutations that are present in all cancer cells is therefore critical for each patient.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.466 (2012)

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关键词翻译
关键词翻译
  • carcinoma 癌症
  • gastric 胃的
  • heterogeneity 不均匀性
  • somatic 躯体的
  • trunk 
  • immunotherapy 免疫疗法
  • Cancer 巨蟹座
  • cancer 癌症
  • mutation 变种
  • therefore 因此