Current Trends in Ligand Binding Real-Time Measurement Technologies
作者: Stephanie FraserJudy Y. ShihMark WareEdward O’ConnorMark J. CameronMartin SchwickartXuemei ZhaoKarin Regnstrom
作者单位: 1Pfizer
2Amgen Inc.
3Janssen Research & Development, LLC
4AegisBioconsult
5Lumigen
6MedImmune
7Merck Research Laboratories
8Boehringer Ingelheim
刊名: The AAPS Journal, 2017, Vol.19 (3), pp.682-691
来源数据库: Springer Journal
DOI: 10.1208/s12248-017-0067-7
关键词: Emergent technology reviewLateral flow immunoassayLigand binding assayReal-time measurementSurface plasmon resonance
英文摘要: Numerous advances in ligand binding assay (LBA) real-time measurement technologies have been made within the last several years, ranging from the development of novel platforms to drive technology expansion to the adaptation of existing platforms to optimize performance and throughput. In this review, we have chosen to focus on technologies that provide increased value to two distinct segments of the LBA community. First, experimentally, by measuring real-time binding events, these technologies provide data that can be used to interrogate receptor/ligand binding interactions. While overall the platforms are not new, they have made significant advances in throughput, multiplexing, and/or sensitivity. Second, clinically, these point-of-care (POC) technologies provide instantaneous...
原始语种摘要: Numerous advances in ligand binding assay (LBA) real-time measurement technologies have been made within the last several years, ranging from the development of novel platforms to drive technology expansion to the adaptation of existing platforms to optimize performance and throughput. In this review, we have chosen to focus on technologies that provide increased value to two distinct segments of the LBA community. First, experimentally, by measuring real-time binding events, these technologies provide data that can be used to interrogate receptor/ligand binding interactions. While overall the platforms are not new, they have made significant advances in throughput, multiplexing, and/or sensitivity. Second, clinically, these point-of-care (POC) technologies provide instantaneous...
全文获取路径: Springer  (合作)
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影响因子:4.386 (2012)

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关键词翻译
关键词翻译
  • provide 规定
  • development 开发
  • information 报告
  • immunoassay 免疫测定法
  • technology 工艺
  • review 复审
  • measuring 测量
  • years 年代
  • measurement 测量
  • plasmon 细胞质基因