The attenuation of renal fibrosis by histone deacetylase inhibitors is associated with the plasticity of FOXP3 + IL-17 + T cells
作者: Wen-Pyng WuYi-Giien TsaiTze-Yi LinMing-Ju WuChing-Yuang Lin
作者单位: 1College of Medicine, China Medical University
2Ching Chyuan Hospital
3Changhua Christian Hospital
4Kaohsiung Medical University
5School of Medicine, Chung-Shan Medical University
6China Medical University Hospital
7Taichung Veterans General Hospital
8National Yang Ming University
9Graduate Institute of Biomedical Science, National Chung Hsing University
刊名: BMC Nephrology, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12882-017-0630-6
关键词: Unilateral ureteric obstructionRenal fibrosisTgf-βFOXP3+ IL-17+ T cells
英文摘要: The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4+ forkhead box P3 (FOXP3)+ T regulatory (Treg) cells may be converted to inflammation-associated T helper 17 cells (Th17) with tissue fibrosis properties. The association between FOXP3+IL-17+ T cells and the attenuation of renal fibrosis by the HDAC inhibitor is not clear.
原始语种摘要: The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4+ forkhead box P3 (FOXP3)+ T regulatory (Treg) cells may be converted to inflammation-associated T helper 17 cells (Th17) with tissue fibrosis properties. The association between FOXP3+IL-17+ T cells and the attenuation of renal fibrosis by the HDAC inhibitor is not clear.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:1.644 (2012)

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关键词翻译
关键词翻译
  • fibrosis 纤维化
  • renal 肾的
  • deacetylase 脱乙酰基酶
  • attenuation 衰减
  • histone 组蛋白
  • ureteric 输尿管的
  • obstruction 塞住
  • forkhead 叉头
  • associated 相关的
  • epigenetic 后成的