Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture
作者: Yingfei XueCynthia St. HilaireLuis HortellsJulie A. PhillippiVinayak SantShilpa Sant
作者单位: 1University of Pittsburgh School of Pharmacy
2University of Pittsburgh
3University of Pittsburgh Swanson School of Engineering
刊名: Cellular and Molecular Bioengineering, 2017, Vol.10 (5), pp.483-500
来源数据库: Springer Journal
DOI: 10.1007/s12195-017-0495-6
关键词: NanoceriaReactive oxygen species (ROS)Valve calcificationPatient-derived valvular interstitial cells (hVICs)Cerium oxide nanoparticleNanoparticle shape
英文摘要: Lack of effective pharmacological treatment makes valvular calcification a significant clinical problem in patients with valvular disease and bioprosthetic/mechanical valve replacement therapies. Elevated levels of reactive oxygen species (ROS) in valve tissue have been identified as a prominent hallmark and driving factor for valvular calcification. However, the therapeutic value of ROS-modulating agents for valvular calcification remains elusive. We hypothesized that ROS-modulating shape-specific cerium oxide nanoparticles (CNPs) will inhibit oxidative stress-induced valvular calcification. CNPs are a class of self-regenerative ROS-modulating agents, which can switch between Ce3+ and Ce4+ in response to oxidative microenvironment. In this work, we developed...
原始语种摘要: Lack of effective pharmacological treatment makes valvular calcification a significant clinical problem in patients with valvular disease and bioprosthetic/mechanical valve replacement therapies. Elevated levels of reactive oxygen species (ROS) in valve tissue have been identified as a prominent hallmark and driving factor for valvular calcification. However, the therapeutic value of ROS-modulating agents for valvular calcification remains elusive. We hypothesized that ROS-modulating shape-specific cerium oxide nanoparticles (CNPs) will inhibit oxidative stress-induced valvular calcification. CNPs are a class of self-regenerative ROS-modulating agents, which can switch between Ce3+ and Ce4+ in response to oxidative microenvironment. In this work, we developed...
全文获取路径: Springer  (合作)
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影响因子:1.443 (2012)

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关键词翻译
关键词翻译
  • valvular 壳瓣的
  • valve 贝壳
  • calcification 钙化
  • interstitial 间隙原子
  • oxidative 氧化的
  • therapeutic 治疗的
  • induced 感应的
  • replacement 交代
  • ROS Read Only Storage
  • modulating 调制的