Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity
作者: Soheila Ali Akbari GhavimiRama Rao TataAndrew J. GreenwaldBrittany N. AllenDavid A. GrantSheila A. GrantMark W. LeeBret D. Ulery
作者单位: 1University of Missouri
刊名: The AAPS Journal, 2017, Vol.19 (4), pp.1029-1044
来源数据库: Springer Journal
DOI: 10.1208/s12248-017-0072-x
关键词: Calcium/phosphate ionsMesenchymal stem cellsMonobasic calcium phosphateOsteoinductionPolyesters
英文摘要: Due to the growing number of patients suffering from musculoskeletal defects and the limited supply of and sub-optimal outcomes associated with biological graft materials, novel biomaterials must be created that can function as graft substitutes. For bone regeneration, composite materials that mimic the organic and inorganic phases of natural bone can provide cues which expedite and enhance endogenous repair. Specifically, recent research has shown that calcium and phosphate ions are inherently osteoinductive, so controllably delivering their release holds significant promise for this field. In this study, unique aliphatic polyesters were synthesized and complexed with a rapidly decomposing ceramic (monobasic calcium phosphate, MCP) yielding novel polymer/ceramic composite biomaterials....
原始语种摘要: Due to the growing number of patients suffering from musculoskeletal defects and the limited supply of and sub-optimal outcomes associated with biological graft materials, novel biomaterials must be created that can function as graft substitutes. For bone regeneration, composite materials that mimic the organic and inorganic phases of natural bone can provide cues which expedite and enhance endogenous repair. Specifically, recent research has shown that calcium and phosphate ions are inherently osteoinductive, so controllably delivering their release holds significant promise for this field. In this study, unique aliphatic polyesters were synthesized and complexed with a rapidly decomposing ceramic (monobasic calcium phosphate, MCP) yielding novel polymer/ceramic composite biomaterials....
全文获取路径: Springer  (合作)
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影响因子:4.386 (2012)

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关键词翻译
关键词翻译
  • phosphate 磷酸盐
  • polyester 聚酯
  • dissolution 溶解
  • release 释放
  • calcium 
  • Release 免除释放机构
  • regenerative 再生放大
  • osteogenic 成骨的
  • cells 麻风细胞
  • mesenchymal 间叶细胞的