Ex vivo 18 O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway
作者: Erik PorteliusNiklas MattssonJosef PanneeHenrik ZetterbergMagnus GisslénHugo VandersticheleEleni GkanatsiouGabriela A. N. CrespiMichael W. ParkerLuke A. MilesJohan GobomKaj Blennow
作者单位: 1The Sahlgrenska Academy at University of Gothenburg
2Sahlgrenska University Hospital, University Hospital
3Lund University
4Skåne University Hospital
5UCL Institute of Neurology
6University of Gothenburg
7ADx Neurosciences
8St. Vincent’s Institute of Medical Research
9University of Melbourne
刊名: Molecular Neurodegeneration, 2017, Vol.12 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13024-017-0152-5
关键词: Amyloid βMass spectrometryStable isotope labelingCerebrospinal fluidInsulin-degrading enzyme
英文摘要: Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptides, the main pathway of Aβ degradation in vivo is unknown. Cerebrospinal fluid (CSF) Aβ42 is reduced in AD, reflecting aggregation and deposition in the brain, but low CSF Aβ42 is, for unknown reasons, also found in some inflammatory brain disorders such as bacterial meningitis.
原始语种摘要: Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptides, the main pathway of Aβ degradation in vivo is unknown. Cerebrospinal fluid (CSF) Aβ42 is reduced in AD, reflecting aggregation and deposition in the brain, but low CSF Aβ42 is, for unknown reasons, also found in some inflammatory brain disorders such as bacterial meningitis.
全文获取路径: Springer  (合作)
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影响因子:4.007 (2012)

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关键词翻译
关键词翻译
  • degradation 减嚣夷酌
  • degrading 冲深
  • spectrometry 光谱测定
  • amyloid 淀粉状朊
  • degrade 降低
  • studied 学习
  • bacterial 细菌的
  • labeling 加标
  • pathway 轨道
  • enzyme