Role of TIM-3 in ovarian cancer
作者: Y. XuH. ZhangY. HuangX. RuiF. Zheng
作者单位: 1The Third Affiliated Hospital of Soochow University
2University of South Florida
刊名: Clinical and Translational Oncology, 2017, Vol.19 (9), pp.1079-1083
来源数据库: Springer Journal
DOI: 10.1007/s12094-017-1656-8
关键词: TIM-3Ovarian cancerBlockade
英文摘要: Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer.
原始语种摘要: Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer.
全文获取路径: Springer  (合作)
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影响因子:1.276 (2012)

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关键词翻译
关键词翻译
  • TIM 终端接口模件
  • ovarian 卵巢的
  • cancer 癌症
  • immunotherapy 免疫疗法
  • innate 先天的
  • immune 免疫的
  • inhibitive 压制
  • immunity 免疫
  • leads 引线
  • therapeutic 治疗的