Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin αvβ3/FAK/PI3K pathway-mediated Rac1 activation
作者: Hao XuYuan YuanWenqian WuMin ZhouQian JiangLinjun NiuJiayin JiNianli LiuLongzhen ZhangXia Wang
作者单位: 1The Affiliated Hospital of Xuzhou Medical University
2Xuzhou Medical University
刊名: Journal of Biosciences, 2017, Vol.42 (3), pp.491-499
来源数据库: Springer Nature Journal
DOI: 10.1007/s12038-017-9699-0
关键词: Cervical cancerHypoxiaRab11Rac1Αvβ3/FAK/PI3K
原始语种摘要: Hypoxia plays a key role in tumour cell survival, invasion, and metastasis. An increasing number of studies have attempted to characterize the tumour response to hypoxia and to identify predictive markers of disease. Here we show that hypoxia increases tumour cell invasion and migration by the modulation of Rab11, an important molecule for vesicular trafficking. In our study, we found that Rab11, together with the activation of Rac1, could stimulate invasion and migration of cervical cancer cell lines HeLa/SiHa in hypoxia. Activation of Rac1 activity by hypoxia seems to be central to carcinoma invasion. We also found that these effects could be related to the integrin αvβ3. In addition, we studied the molecular pathway for this process. Our results showed that in cervical cancer cell...
全文获取路径: Springer Nature  (合作)
影响因子:1.759 (2012)

  • cervical 颈的
  • hypoxia 氧过少
  • activation 活化
  • invasion 侵入
  • pathway 轨道
  • migration 迁移
  • lines 线型
  • cancer 癌症
  • integrin 整联蛋白
  • stimulate 刺激