Evaluating the Effects of an Ophthalmic Solution of Coenzyme Q10 and Vitamin E in Open-Angle Glaucoma Patients: A Study Protocol
作者: Luciano QuarantaIvano RivaElena BiagioliErica RulliEliana RulliDavide PoliLorenzo LegramandiMaurizio FossarelloMaurizio UvaLuciana CarmassiStefano GandolfiGemma C. RossiLuigi FontanaTeresa RolleDaniele TognettoLeonardo MastropasquaEmilio CamposCarlo NucciGianluca ScuderiGiorgio Marchini
作者单位: 1Department of Surgical & Clinical, Diagnostic and Pediatric Sciences, Section of Ophthalmology, University of Pavia, IRCCS Fondazione Policlinico San Matteo
2IRCCS – Fondazione Bietti
3Laboratory of Methodology for Clinical Research, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
刊名: Advances in Therapy, 2019, Vol.36 (9), pp.2506-2514
来源数据库: Springer Journal
DOI: 10.1007/s12325-019-01023-3
关键词: Coenzyme Q10Open-angle glaucomaOphthalmologyProstaglandin analogueRandomized clinical trialVitamin E
英文摘要: Abstract(#br) Introduction(#br)The CoQun ® study is a multicenter, controlled trial aimed to evaluate the neuroprotective effects of Coqun ® , an ophthalmic solution of Coenzyme q10 (CoQ10) and Vitamin E (VitE), in patients affected by primary open-angle glaucoma (POAG). Pre-clinical studies and small non-controlled clinical trials have previously shown a potential role of CoQ10 and VitE in glaucoma neuroprotection, both in vitro and in vivo.(#br) Methods(#br)Randomized, parallel arm, multicenter, double-blind study. POAG patients with an IOP ranging from 17 to 21 mm Hg on monotherapy with a prostaglandin analogue (PGA) will be considered for study enrollment. Inclusion criteria will be visual field (VF) mean deviation between − 4 and − 10 dB and VF Pattern Standard Deviation between 4...
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影响因子:2.125 (2012)

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