Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence
作者: Fanfan DuYu-Gang LiuEvan Alexander Scott
作者单位: 1Northwestern University
2Northwestern University Feinberg School of Medicine
刊名: Cellular and Molecular Bioengineering, 2017, Vol.10 (5), pp.357-370
来源数据库: Springer Journal
DOI: 10.1007/s12195-017-0486-7
关键词: PolymersomeFluorescenceTheranosticsPeryleneMacrophageDendritic cell
英文摘要: Intracellular delivery is a key step for many applications in medicine and for investigations into cellular function. This is particularly true for immunotherapy, which often requires controlled delivery of antigen and adjuvants to the cytoplasm of immune cells. Due to the complex responses generated by the stimulation of diverse immune cell populations, it is critical to monitor which cells are targeted during treatment. To address this issue, we have engineered an immunotheranostic polymersome delivery system that fluorescently marks immune cells following intracellular delivery.
原始语种摘要: Intracellular delivery is a key step for many applications in medicine and for investigations into cellular function. This is particularly true for immunotherapy, which often requires controlled delivery of antigen and adjuvants to the cytoplasm of immune cells. Due to the complex responses generated by the stimulation of diverse immune cell populations, it is critical to monitor which cells are targeted during treatment. To address this issue, we have engineered an immunotheranostic polymersome delivery system that fluorescently marks immune cells following intracellular delivery.
全文获取路径: Springer  (合作)
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影响因子:1.443 (2012)

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关键词翻译
关键词翻译
  • immune 免疫的
  • Fluorescence 荧光
  • delivery 移交
  • immunotherapy 免疫疗法
  • stimulation 激励
  • medicine 
  • cells 麻风细胞
  • intracellular 胞内的
  • antigen 抗原
  • following 追踪