Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer
作者: Yan DongZhe WangGan-feng XieChong LiWen-wei ZuoGang MengCheng-ping XuJian-jun Li
作者单位: 1Third Military Medical University
刊名: Molecular Cancer, 2017, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12943-017-0641-8
关键词: Colorectal cancerChemotherapy resistancePXRMRP3Transcriptional regulationOverall survival
英文摘要: Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and transportation, but the regulatory mechanism is poorly understood.
原始语种摘要: Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and transportation, but the regulatory mechanism is poorly understood.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:5.134 (2012)

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关键词翻译
关键词翻译
  • survival 生存
  • unfavorable 不利
  • colorectal 结肠直肠的
  • activating 激活
  • cancer 癌症
  • receptor 接受体
  • protein 蛋白质
  • chemotherapy 化学疗法
  • associated 相关的
  • therapeutic 治疗的