Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival
作者: Joel M. BaumgartnerVictoria M. RaymondRichard B. LanmanLisa TranKaitlyn J. KellyAndrew M. LowyRazelle Kurzrock
作者单位: 1Department of Surgery, Division of Surgical Oncology, University of California, San Diego
2Guardant Health, Inc
3Center for Personalized Cancer Therapy, University of California, San Diego
刊名: Annals of Surgical Oncology, 2018, Vol.25 (8), pp.2400-2408
来源数据库: Springer Nature Journal
DOI: 10.1245/s10434-018-6561-z
英文摘要: Abstract(#br) Background(#br)Next-generation sequencing (NGS) is a useful tool for detecting genomic alterations in circulating tumor DNA (ctDNA). To date, most ctDNA tests have been performed on patients with widely metastatic disease. Patients with peritoneal carcinomatosis (metastases) present unique prognostic and therapeutic challenges. We therefore explored preoperative ctDNA in patients with peritoneal metastases undergoing surgery.(#br) Methods(#br)Patients referred for surgical resection of peritoneal metastases underwent preoperative blood-derived ctDNA analysis (clinical-grade NGS [68–73 genes]). ctDNA was quantified as the percentage of altered circulating cell-free DNA (% cfDNA).(#br) Results(#br)Eighty patients had ctDNA testing: 46 (57.5%) women; median age 55.5 years. The...
全文获取路径: Springer Nature  (合作)
影响因子:4.12 (2012)