Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice
作者: Alessandra BittoDaniela GiulianiGiovanni PallioNatasha IrreraEleonora VandiniFabrizio CanaliniDavide ZaffeAlessandra OttaniLetteria MinutoliMariagrazia RinaldiSalvatore GuariniFrancesco SquadritoDomenica Altavilla
作者单位: 1University of Messina
2University of Modena and Reggio Emilia
刊名: Inflammation Research, 2017, Vol.66 (5), pp.389-398
来源数据库: Springer Journal
DOI: 10.1007/s00011-017-1022-x
关键词: BaicalinCatechinAlzheimerNLRP3NeurodegenerationMemory
英文摘要: Alzheimer’s disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain. We investigated the possible neuroprotective role of flavocoxid, a dual inhibitor of cyclooxygenases-1/2 (COX-1/2) and 5-Lipoxygenase (5-LOX), in triple-transgenic (3xTg-AD) mice.
原始语种摘要: Alzheimer’s disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain. We investigated the possible neuroprotective role of flavocoxid, a dual inhibitor of cyclooxygenases-1/2 (COX-1/2) and 5-Lipoxygenase (5-LOX), in triple-transgenic (3xTg-AD) mice.
全文获取路径: Springer  (合作)
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影响因子:1.964 (2012)

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关键词翻译
关键词翻译
  • blockade 封闭
  • amyloid 淀粉状朊
  • protein 蛋白质
  • associated 相关的
  • disease 
  • brain 
  • triple 三重的
  • possible 可能的
  • inhibitor 抑制剂