Micelles of polylactide–poly(ethylene glycol)–polylactide (LA n –EG m –LA n ) triblock copolymers as insulin delivery system: spectroscopic studies
作者: Pouneh Sadat PourhosseiniReza AmaniAli Akbar SabouryFarhood NajafiMohammad Imani
作者单位: 1Alzahra University
2University of Tehran
3Institute for Color Science and Technology
4Iran Polymer and Petrochemical Institute
刊名: Journal of the Iranian Chemical Society, 2017, Vol.14 (12), pp.2637-2648
来源数据库: Springer Journal
DOI: 10.1007/s13738-017-1198-6
关键词: InsulinCircular dichroism (CD)Fluorescence spectroscopyPolylactide (PLA)Triblock copolymer
英文摘要: A series of triblock copolymers are synthesized by the ring-opening polymerization of l -lactide in the presence of PEG of various molecular weights. Firstly, the (lactic acid) n –(ethylene glycol) m –(lactic acid) n (LA n –EG m –LA n ) copolymers are characterized by 1H NMR and GPC studies. Micelles, prepared in aqueous media by the direct dissolution method, are characterized by TEM and DLS. In vitro release behavior of bovine insulin from LA37–EG136–LA37 micelles is evaluated at 37 °C. According to results, nearly 90 wt% of insulin is released over 6 days by diffusion in a biphasic pattern. Secondly, a comparative study of the interactions occurring between insulin (both...
原始语种摘要: A series of triblock copolymers are synthesized by the ring-opening polymerization of l -lactide in the presence of PEG of various molecular weights. Firstly, the (lactic acid) n –(ethylene glycol) m –(lactic acid) n (LA n –EG m –LA n ) copolymers are characterized by 1H NMR and GPC studies. Micelles, prepared in aqueous media by the direct dissolution method, are characterized by TEM and DLS. In vitro release behavior of bovine insulin from LA37–EG136–LA37 micelles is evaluated at 37 °C. According to results, nearly 90 wt% of insulin is released over 6 days by diffusion in a biphasic pattern. Secondly, a comparative study of the interactions occurring between insulin (both...
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影响因子:1.467 (2012)

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关键词翻译
关键词翻译
  • polylactide 聚交酯
  • copolymer 共聚物
  • spectroscopic 光谱的
  • insulin 胰岛素
  • glycol 甘醇
  • ethylene 乙烯
  • biphasic 双相的
  • interaction 相互酌
  • spectroscopy 分光学
  • shielded 遮蔽的