Leptin differentially regulates chondrogenesis in mouse vertebral and tibial growth plates
作者: Bo YuKaibiao JiangBin ChenHantao WangXinfeng LiZude Liu
作者单位: 1Shanghai Jiao Tong University
刊名: BMC Musculoskeletal Disorders, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12891-017-1601-6
关键词: LeptinChondrogenesisVertebral growth plateTibial growth platePrimary cell cultureChondrocyte
英文摘要: Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene that encodes leptin receptors, is vertebral and appendicular region-specific, suggesting the regulation of leptin on VGP and TGP chondrogenesis may be very different. The aim of the present study was to investigate the differential regulation of leptin on the chondrogenesis of vertebral growth plate (VGP) and tibial growth plate (TGP).
原始语种摘要: Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene that encodes leptin receptors, is vertebral and appendicular region-specific, suggesting the regulation of leptin on VGP and TGP chondrogenesis may be very different. The aim of the present study was to investigate the differential regulation of leptin on the chondrogenesis of vertebral growth plate (VGP) and tibial growth plate (TGP).
全文获取路径: Springer  (合作)
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影响因子:1.875 (2012)

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关键词翻译
关键词翻译
  • vertebral 脊椎的
  • tibial 胫骨的
  • chondrogenesis 软骨形成
  • growth 生长
  • plate 
  • spine 火山碑
  • mouse 小鼠
  • expression 表示
  • specific 
  • region 地域