Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methods
作者: Nada S. AbdelwahabHeba A. H. ElshemyNehal F. Farid
作者单位: 1Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-suef University
2Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University (NUB)
3Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University
刊名: Chemistry Central Journal, 2018, Vol.12 (1), pp.1-15
来源数据库: Springer Nature Journal
DOI: 10.1186/s13065-018-0372-y
关键词: FlutamideMetabolitesHPTLCHPLCPlasmaUrine
英文摘要: Abstract(#br)Flutamide is a potential antineoplastic drug classified as an anti-androgen. It is a therapy for men with advanced prostate cancer, administered orally after which it undergoes extensively first pass metabolism in the liver with the production of several metabolites. These metabolites are predominantly excreted in urine. One of the important metabolites in plasma is 4-nitro-3-(trifluoromethyl)phenylamine (Flu-1), while the main metabolite in urine is 2-amino-5-nitro-4-(trifluoromethyl)phenol (Flu-3). In this work the two metabolites, Flu-1 and Flu-3, have been synthesized, and then structural confirmation has been carried out by HNMR analysis. Efforts were exerted to develop chromatographic methods for resolving Flutamide and its metabolites with the use of acceptable...
全文获取路径: Springer Nature  (合作)
影响因子:1.312 (2012)