Amalaki Rasayana improved memory and neuronal metabolic activity in AβPP-PS1 mouse model of Alzheimer’s disease
作者: Vivek TiwariKamal SabaPandichelvam VeeraiahJedy JoseSubhash C LakhotiaAnant B Patel
作者单位: 1CSIR–Centre for Cellular and Molecular Biology
2Banaras Hindu University
刊名: Journal of Biosciences, 2017, Vol.42 (3), pp.363-371
来源数据库: Springer Journal
DOI: 10.1007/s12038-017-9692-7
关键词: Alzheimer’s disease13C nuclear magneticGABAGlutamateNeurotransmitter cycleResonance spectroscopy
英文摘要: Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by progressive loss of memory and cognitive function. The cerebral metabolic rate of glucose oxidation has been shown to be reduced in AD. The present study evaluated efficacy of dietary Amalaki Rasayana (AR), an Ayurvedic formulation used in Indian traditional system, in AβPP-PS1 mouse model of AD in ameliorating memory and neurometabolism, and compared with donepezil, a standard FDA approved drug for AD. The memory of mice was measured using Morris Water Maze analysis. The cerebral metabolism was followed by 13C labelling of brain amino acids in tissue extracts ex vivo using 1H-[13C]-NMR spectroscopy together with a short time infusion of...
原始语种摘要: Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by progressive loss of memory and cognitive function. The cerebral metabolic rate of glucose oxidation has been shown to be reduced in AD. The present study evaluated efficacy of dietary Amalaki Rasayana (AR), an Ayurvedic formulation used in Indian traditional system, in AβPP-PS1 mouse model of AD in ameliorating memory and neurometabolism, and compared with donepezil, a standard FDA approved drug for AD. The memory of mice was measured using Morris Water Maze analysis. The cerebral metabolism was followed by 13C labelling of brain amino acids in tissue extracts ex vivo using 1H-[13C]-NMR spectroscopy together with a short time infusion of...
全文获取路径: Springer  (合作)
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影响因子:1.759 (2012)

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关键词翻译
关键词翻译
  • 标准 函数
  • improved 改进
  • memory 记忆
  • approved 认可的
  • model 模型
  • activity 活度
  • mouse 小鼠
  • together 共同
  • GABA 伽马氨基丁酸
  • function 函数
  • standard 函数