Cellular fatty acid synthase is required for late stages of HIV-1 replication
作者: Manjusha M. KulkarniAnnette N. RatcliffMenakshi BhatYazan AlwarawrahPhilip HughesJesus ArcosDavid LoiselleJordi B. TorrellesNicholas T. FunderburgTimothy A. HaysteadJesse J. Kwiek
作者单位: 1The Ohio State University
2Promega Corporation
3Duke University School of Medicine
4Texas Biomedical Research Institute
刊名: Retrovirology, 2017, Vol.14 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12977-017-0368-z
关键词: Human immunodeficiency virus type 1Host-virus interactionFatty acid synthaseAntiviral pharmacologyFasnall
英文摘要: Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many existing drugs target purine-using enzymes. Leveraging a protein affinity media that uses the purine-binding pocket to capture the entire purinome, we sought to define purine-binding proteins regulated by HIV-1 infection.
原始语种摘要: Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many existing drugs target purine-using enzymes. Leveraging a protein affinity media that uses the purine-binding pocket to capture the entire purinome, we sought to define purine-binding proteins regulated by HIV-1 infection.
全文获取路径: Springer  (合作)
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影响因子:5.657 (2012)

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关键词翻译
关键词翻译
  • synthase 合酶
  • required 必需
  • fatty 脂肪的
  • purine 嘌呤
  • proteins 蛋白质
  • HIV Hydraulic Isolation Valve
  • replication 复制
  • binding 装订
  • virus 病毒
  • pharmacology 药理学