Nanomaterials for the Capture and Therapeutic Targeting of Circulating Tumor Cells
作者: Zhenjiang ZhangMichael R. King
作者单位: 1Vanderbilt University
刊名: Cellular and Molecular Bioengineering, 2017, Vol.10 (4), pp.275-294
来源数据库: Springer Journal
DOI: 10.1007/s12195-017-0497-4
关键词: CancerMetastasisCirculating tumor cellsNanomedicineNanomaterialsNanoparticles
英文摘要: Circulating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and isolate them with high efficiency. Nanomaterials, with unique structural and functional properties, have shown strong promise to meet the challenging demands. In this review, we discuss CTC capture and therapeutic targeting, emphasizing the significance of the nanomaterials being used for this purpose. The next generation of therapy for metastatic cancer may well involve capturing and even directly neutralizing CTCs...
原始语种摘要: Circulating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and isolate them with high efficiency. Nanomaterials, with unique structural and functional properties, have shown strong promise to meet the challenging demands. In this review, we discuss CTC capture and therapeutic targeting, emphasizing the significance of the nanomaterials being used for this purpose. The next generation of therapy for metastatic cancer may well involve capturing and even directly neutralizing CTCs...
全文获取路径: Springer  (合作)
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影响因子:1.443 (2012)

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关键词翻译
关键词翻译
  • targeting 导向目标
  • therapeutic 治疗的
  • neutralizing 中和
  • cells 麻风细胞
  • cancer 癌症
  • metastasis 同质蜕变
  • capture 捕获
  • directly 直接
  • promise 允诺
  • structural 构造