Multiple oncogenic roles of nuclear β-catenin
作者: Raju KumarMurali D Bashyam
作者单位: 1Centre for DNA Fingerprinting and Diagnostics
2Manipal University
刊名: Journal of Biosciences, 2017, Vol.42 (4), pp.695-707
来源数据库: Springer Nature Journal
DOI: 10.1007/s12038-017-9710-9
关键词: Anti-tumour immunityCancer cell metabolismEpithelial-mesenchymal transitionTumour-initiating cellsTumour micro-environment
原始语种摘要: β-Catenin is essential for embryonic development and required for cell renewal/regeneration in adult life. Cellular β-catenin exists in three different pools: membranous, cytoplasmic and nuclear. In this review, we focus on functions of the nuclear pool in relation to tumorigenesis. In the nucleus, β-catenin functions as both activator and repressor of transcription in a context-dependent manner. It promotes cell proliferation and supports tumour growth by enhancing angiogenesis. β-Catenin-mediated signalling regulates cancer cell metabolism and is associated with tumour-initiating cells in multiple malignancies. In addition, it functions as both pro- and anti-apoptotic factor besides acting to inhibit recruitment of inflammatory anti-tumour T-cells. Thus, β-catenin appears to possess a...
全文获取路径: Springer Nature  (合作)
影响因子:1.759 (2012)

  • 代谢 多层面的
  • oncogenic 致癌的
  • tumour 肿瘤
  • nuclear 原子核的
  • tumorigenesis 瘤形成
  • cells 麻风细胞
  • mesenchymal 间叶细胞的
  • multifaceted 多层面的
  • metabolism 多层面的
  • recruitment 补充
  • initiating 启动