Chemoprotection Across the Tumor Border: Cancer Cell Response to Doxorubicin Depends on Stromal Fibroblast Ratios and Interstitial Therapeutic Transport
| 作者： | Daniel K. Logsdon, Garrett F. Beeghly, Jennifer M. Munson |
| 作者单位： |
1University of Virginia School of Medicine 2Virginia Tech |
| 刊名： | Cellular and Molecular Bioengineering, 2017, Vol.10 (5), pp.463-481 |
| 来源数据库： | Springer Nature Journal |
| DOI： | 10.1007/s12195-017-0498-3 |
| 关键词： | Tumor microenvironment; Drug delivery; Doxorubicin; Fibroblasts; Breast cancer; Interstitial flow; 3D cell culture; |
| 原始语种摘要： | Increasing evidence suggests that the tumor microenvironment reduces therapeutic delivery and may lead to chemotherapeutic resistance. At tumor borders, drug is convectively transported across a unique microenvironment composed of inverse gradients of stromal and tumor cells. These regions are particularly important to overall survival, as they are often missed through surgical intervention and contain many invading cells, often responsible for metastatic spread. An understanding of how cells in this tumor-border region respond to chemotherapy could begin to elucidate the role of transport and intercellular interactions in relation to chemoresistance. Here we examine the contribution of drug transport and stromal fibroblasts to breast cancer response to doxorubicin using in silico and in... |
