Chemoprotection Across the Tumor Border: Cancer Cell Response to Doxorubicin Depends on Stromal Fibroblast Ratios and Interstitial Therapeutic Transport
作者: Daniel K. LogsdonGarrett F. BeeghlyJennifer M. Munson
作者单位: 1University of Virginia School of Medicine
2Virginia Tech
刊名: Cellular and Molecular Bioengineering, 2017, Vol.10 (5), pp.463-481
来源数据库: Springer Journal
DOI: 10.1007/s12195-017-0498-3
关键词: Tumor microenvironmentDrug deliveryDoxorubicinFibroblastsBreast cancerInterstitial flow3D cell culture
英文摘要: Increasing evidence suggests that the tumor microenvironment reduces therapeutic delivery and may lead to chemotherapeutic resistance. At tumor borders, drug is convectively transported across a unique microenvironment composed of inverse gradients of stromal and tumor cells. These regions are particularly important to overall survival, as they are often missed through surgical intervention and contain many invading cells, often responsible for metastatic spread. An understanding of how cells in this tumor-border region respond to chemotherapy could begin to elucidate the role of transport and intercellular interactions in relation to chemoresistance. Here we examine the contribution of drug transport and stromal fibroblasts to breast cancer response to doxorubicin using in silico and in...
原始语种摘要: Increasing evidence suggests that the tumor microenvironment reduces therapeutic delivery and may lead to chemotherapeutic resistance. At tumor borders, drug is convectively transported across a unique microenvironment composed of inverse gradients of stromal and tumor cells. These regions are particularly important to overall survival, as they are often missed through surgical intervention and contain many invading cells, often responsible for metastatic spread. An understanding of how cells in this tumor-border region respond to chemotherapy could begin to elucidate the role of transport and intercellular interactions in relation to chemoresistance. Here we examine the contribution of drug transport and stromal fibroblasts to breast cancer response to doxorubicin using in silico and in...
全文获取路径: Springer  (合作)
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影响因子:1.443 (2012)

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关键词翻译
关键词翻译
  • chemotherapy 化学疗法
  • Cancer 巨蟹座
  • survival 生存
  • therapeutic 治疗的
  • breast 胸部
  • cells 麻风细胞
  • intervention 
  • doxorubicin 阿霉素
  • delivery 移交
  • responsible 负责的