Viscoelasticity Measurements Reveal Rheological Differences Between Stem-like and Non-stem-like Breast Cancer Cells
作者: A. MohammadalipourM. M. BurdickD. F. J. Tees
作者单位: 1Ohio University
刊名: Cellular and Molecular Bioengineering, 2017, Vol.10 (3), pp.235-248
来源数据库: Springer Journal
DOI: 10.1007/s12195-017-0485-8
关键词: Cancer stem cellsMechanical propertiesMechanical biomarkerMicropipette aspirationIntracellular particle trackingMicrorheologyCytoskeleton
英文摘要: Defining the characteristics of cancer stem cells (CSC) has become an important subject in cancer research during the past decade. Although molecular surface expression levels have been used for CSC recognition, the clinical and prognostic impacts of these markers have remained a controversial issue. The finding that cancerous cells are considerably more deformable than normal ones provides the motivation for the hypothesis that the mechanical properties can be used as biomarkers to distinguish between stem-like and non-stem-like cancer cells. In this study, using micropipette aspiration (MA) and intracellular particle tracking (IPT) microrheology, measurements of the whole-cell and local viscoelasticity were made on four breast cancer cell lines with different CSC phenotypes based on...
原始语种摘要: Defining the characteristics of cancer stem cells (CSC) has become an important subject in cancer research during the past decade. Although molecular surface expression levels have been used for CSC recognition, the clinical and prognostic impacts of these markers have remained a controversial issue. The finding that cancerous cells are considerably more deformable than normal ones provides the motivation for the hypothesis that the mechanical properties can be used as biomarkers to distinguish between stem-like and non-stem-like cancer cells. In this study, using micropipette aspiration (MA) and intracellular particle tracking (IPT) microrheology, measurements of the whole-cell and local viscoelasticity were made on four breast cancer cell lines with different CSC phenotypes based on...
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影响因子:1.443 (2012)

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关键词翻译
关键词翻译
  • deformable 可变形的
  • deformability 形变能力
  • recognition 识别
  • cells 麻风细胞
  • micropipette 微量吸移管
  • properties 道具
  • cancerous 癌性的
  • aspiration 愿望
  • microrheology 微观流变学
  • lines 线型