Dosimetry methods and clinical applications in peptide receptor radionuclide therapy for neuroendocrine tumours: a literature review
作者: Daphne Merel Valerie HuizingBerlinda Jantina de Wit-van der VeenMarcel VerheijMarcellus Petrus Maria Stokkel
作者单位: 1Department of Nuclear Medicine, Netherlands Cancer Institute
2Department of Radiation Oncology, Netherlands Cancer Institute
刊名: EJNMMI Research, 2018, Vol.8 (1), pp.1-11
来源数据库: Springer Journal
DOI: 10.1186/s13550-018-0443-z
关键词: DosimetrySystemic radiation therapyPRRTAbsorbed doseNeuroendocrine tumours
英文摘要: Abstract(#br) Background(#br)The main challenge for systemic radiation therapy using radiopharmaceuticals (SRT) is to optimise the dose delivered to the tumour, while minimising normal tissue irradiation. Dosimetry could help to increase therapy response and decrease toxicity after SRT by individual treatment planning. Peptide receptor radionuclide therapy (PRRT) is an accepted SRT treatment option for irresectable and metastatic neuroendocrine tumours (NET). However, dosimetry in PRRT is not routinely performed, mainly due to the lack of evidence in literature and clinical implementation difficulties. The goal of this review is to provide insight in dosimetry methods and requirements and to present an overview of clinical aspects of dosimetry in PRRT for NET.(#br) Methods(#br)A PubMed...
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