Short-term increase in prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus following mass drug administration with azithromycin for trachoma control
作者: Ebrima BojangJames JafaliVincent PerretenJohn HartEmma M. Harding-EschAnsumana SillahDavid C. W. MabeyMartin J. HollandRobin L. BaileyAnna RocaSarah E. Burr
作者单位: 1Disease Control and Elimination Theme, Medical Research Council Unit, The Gambia
2University of Bern
3London School of Hygiene and Tropical Medicine
4National Eye Health Programe, Ministry of Health and Social Welfare
5Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
刊名: BMC Microbiology, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12866-017-0982-x
关键词: TrachomaAzithromycinMass drug administrationStaphylococcus aureus carriageMacrolide resistanceIMLSBThe GambiaWest Africa
英文摘要: Mass drug administration (MDA) with azithromycin is a corner-stone of trachoma control however it may drive the emergence of antimicrobial resistance. In a cluster-randomized trial (Clinical trial gov NCT00792922), we compared the reduction in the prevalence of active trachoma in communities that received three annual rounds of MDA to that in communities that received a single treatment round. We used the framework of this trial to carry out an opportunistic study to investigate if the increased rounds of treatment resulted in increased prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus . Three cross-sectional surveys were conducted in two villages receiving three annual rounds of MDA (3 × treatment arm). Surveys were conducted immediately before the third...
原始语种摘要: Mass drug administration (MDA) with azithromycin is a corner-stone of trachoma control however it may drive the emergence of antimicrobial resistance. In a cluster-randomized trial (Clinical trial gov NCT00792922), we compared the reduction in the prevalence of active trachoma in communities that received three annual rounds of MDA to that in communities that received a single treatment round. We used the framework of this trial to carry out an opportunistic study to investigate if the increased rounds of treatment resulted in increased prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus . Three cross-sectional surveys were conducted in two villages receiving three annual rounds of MDA (3 × treatment arm). Surveys were conducted immediately before the third...
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来源刊物:
影响因子:3.104 (2012)

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关键词翻译
关键词翻译
  • nasopharyngeal 鼻咽的
  • resistant 耐久的
  • trachoma 沙眼
  • macrolide 大环内脂
  • administration 管理
  • carriage 运费
  • increase 增加
  • following 追踪
  • prevalence 传播
  • antimicrobial 杀菌剂