Tethered Jagged-1 Synergizes with Culture Substrate Stiffness to Modulate Notch-Induced Myogenic Progenitor Differentiation
作者: Helia SafaeeMohsen A. BakooshliSadegh DavoudiRichard Y. ChengAditya J. MartowirogoEdward W. LiCraig A. SimmonsPenney M. Gilbert
作者单位: 1University of Toronto
2Translational Biology and Engineering Program, The Ted Rogers Centre for Heart Research
3Donnelly Centre for Cellular and Biomolecular Research
刊名: Cellular and Molecular Bioengineering, 2017, Vol.10 (5), pp.501-513
来源数据库: Springer Journal
DOI: 10.1007/s12195-017-0506-7
关键词: Skeletal muscleRegenerationBiophysical cuesBiochemical cuesSpatiotemporalNicheCompression testingExtracellular matrixHydrogelLigand presentation
英文摘要: Notch signaling is amongst the key intrinsic mechanisms regulating satellite cell fate, promoting the transition of activated satellite cells to highly proliferative myogenic progenitor cells and preventing their premature differentiation. Although much is known about the biochemical milieu that drives myogenic progression, less is known about the spatial cues providing spatiotemporal control of skeletal muscle repair in the context of Notch signaling.
原始语种摘要: Notch signaling is amongst the key intrinsic mechanisms regulating satellite cell fate, promoting the transition of activated satellite cells to highly proliferative myogenic progenitor cells and preventing their premature differentiation. Although much is known about the biochemical milieu that drives myogenic progression, less is known about the spatial cues providing spatiotemporal control of skeletal muscle repair in the context of Notch signaling.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:1.443 (2012)

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关键词翻译
关键词翻译
  • myogenic 肌原性的
  • muscle 肌肉
  • presentation 提示
  • providing 只要
  • biochemical 生物化学的
  • regulating 蝶的
  • Regeneration 再生
  • cells 麻风细胞
  • skeletal 骨架
  • progenitor 祖先