Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus
作者: Daniel GonzalezJames M. ChamberlainJeffrey T. GuptillMichael Cohen-WolkowiezBarrie HarperJian ZhaoEdmund V. CapparelliOn behalf of the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee
作者单位: 1The University of North Carolina at Chapel Hill
2Children’s National Medical Center
3Duke Clinical Research Institute
4Duke University School of Medicine
5Emmes Corporation
6University of California
刊名: Clinical Pharmacokinetics, 2017, Vol.56 (8), pp.941-951
来源数据库: Springer Journal
DOI: 10.1007/s40262-016-0486-0
关键词: Status EpilepticusPopulation Pharmacokinetic ModelVirtual PatientVisual Predictive CheckLorazepam Dose
英文摘要: Lorazepam is one of the preferred agents used for intravenous treatment of status epilepticus (SE). We combined data from two pediatric clinical trials to characterize the population pharmacokinetics of intravenous lorazepam in infants and children aged 3 months to 17 years with active SE or a history of SE.
原始语种摘要: Lorazepam is one of the preferred agents used for intravenous treatment of status epilepticus (SE). We combined data from two pediatric clinical trials to characterize the population pharmacokinetics of intravenous lorazepam in infants and children aged 3 months to 17 years with active SE or a history of SE.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:6.109 (2012)

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关键词翻译
关键词翻译
  • characterize 成为...的特性
  • lorazepam 劳拉西泮
  • intravenous 静脉内的
  • clinical 临床的
  • combined 组合
  • pediatric 儿科的
  • preferred 可取
  • status 状态
  • population 母体
  • treatment 处理