Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production
作者: Katarzyna Marta ZoltowskaMasato MaesakoIryna LushnikovaShuko TakedaLaura J. KellerGalina SkiboBradley T. HymanOksana Berezovska
作者单位: 1Massachusetts General Hospital, Harvard Medical School
2National Academy of Sciences of Ukraine
刊名: Molecular Neurodegeneration, 2017, Vol.12 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13024-017-0159-y
关键词: Presenilin 1Synaptotagmin 1SynapseExocytosisAmyloid βAlzheimer’s disease
英文摘要: Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to influence PS1-dependent generation of distinct amyloid β (Aβ) species. However, the precise nature of these regulations remains unclear. The current study reveals novel role of PS1 at the synapse, and deciphers how PS1 and synaptic vesicle-associated protein, synaptotagmin 1 (Syt1) modulate each other functions in neurons via direct activity-triggered interaction. Additionally, the therapeutic potential of fostering PS1-Syt1 binding is investigated as a synapse-specific strategy for AD prevention.
原始语种摘要: Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to influence PS1-dependent generation of distinct amyloid β (Aβ) species. However, the precise nature of these regulations remains unclear. The current study reveals novel role of PS1 at the synapse, and deciphers how PS1 and synaptic vesicle-associated protein, synaptotagmin 1 (Syt1) modulate each other functions in neurons via direct activity-triggered interaction. Additionally, the therapeutic potential of fostering PS1-Syt1 binding is investigated as a synapse-specific strategy for AD prevention.
全文获取路径: Springer  (合作)
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影响因子:4.007 (2012)

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关键词翻译
关键词翻译
  • production 生产
  • amyloid 淀粉状朊
  • exocytosis 胞吐酌
  • protein 蛋白质
  • synapse 突触
  • remains 残渣
  • distinct 相异的
  • associated 相关的
  • triggered 触发的
  • interaction 相互酌