Regulation of dynamin family proteins by post-translational modifications
作者: Usha P KarHimani DeyAbdur Rahaman
作者单位: 1National Institute of Science Education and Research-Bhubaneswar, HBNI
刊名: Journal of Biosciences, 2017, Vol.42 (2), pp.333-344
来源数据库: Springer Journal
DOI: 10.1007/s12038-017-9680-y
关键词: DynaminEndocytosisGTPaseMitochondrial dynamicsPost-translational modification
英文摘要: Dynamin superfamily proteins comprising classical dynamins and related proteins are membrane remodelling agents involved in several biological processes such as endocytosis, maintenance of organelle morphology and viral resistance. These large GTPases couple GTP hydrolysis with membrane alterations such as fission, fusion or tubulation by undergoing repeated cycles of self-assembly/disassembly. The functions of these proteins are regulated by various post-translational modifications that affect their GTPase activity, multimerization or membrane association. Recently, several reports have demonstrated variety of such modifications providing a better understanding of the mechanisms by which dynamin proteins influence cellular responses to physiological and environmental cues. In this...
原始语种摘要: Dynamin superfamily proteins comprising classical dynamins and related proteins are membrane remodelling agents involved in several biological processes such as endocytosis, maintenance of organelle morphology and viral resistance. These large GTPases couple GTP hydrolysis with membrane alterations such as fission, fusion or tubulation by undergoing repeated cycles of self-assembly/disassembly. The functions of these proteins are regulated by various post-translational modifications that affect their GTPase activity, multimerization or membrane association. Recently, several reports have demonstrated variety of such modifications providing a better understanding of the mechanisms by which dynamin proteins influence cellular responses to physiological and environmental cues. In this...
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影响因子:1.759 (2012)

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关键词翻译
关键词翻译
  • translational 平移的
  • proteins 蛋白质
  • family 
  • several 各自
  • demonstrated 探明的储量
  • disassembly 分解
  • membrane 
  • repeated 重复的
  • various 千变万化的
  • tubulation 装管