Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?
作者: Kate A. McBrideMandy L. BallingerTimothy E. SchlubMary-Anne YoungMartin H. N. TattersallJudy KirkRos EelesEmma KillickLeslie G. WalkerSue ShanleyDavid M. ThomasGillian Mitchell
作者单位: 1Western Sydney University
2Sydney School of Public Health
3Garvan Institute of Medical Research
4Peter MacCallum Cancer Centre
5Sydney Medical School
6Crown Princess Mary Cancer Centre
7The Institute of Cancer Research
8University Hospital Southampton NHS Foundation Trust
9University of Hull
10University of Melbourne
刊名: Familial Cancer, 2017, Vol.16 (3), pp.423-432
来源数据库: Springer Journal
DOI: 10.1007/s10689-016-9964-7
关键词: Li-Fraumeni syndromeTP53ScreeningHereditary cancerPsychosocialMixed methods
英文摘要: Germline TP53 mutation carriers are at high risk of developing a range of cancers. Effective cancer risk management is an important issue for these individuals. We assessed the psychosocial impact in TP53 mutation carriers of WB-MRI screening as part of the Surveillance in Multi-Organ Cancer (SMOC+) protocol, measuring their unmet needs, anxiety and depression levels as well as cancer worry using psychological questionnaires and in-depth interviews about their experiences of screening. We present preliminary psychosocial findings from 17 participants during their first 12 months on the trial. We found a significant reduction in participants’ mean anxiety from baseline to two weeks post WB-MRI (1.2, 95% CI 0.17 to 2.23 p = 0.025), indicative of some benefit. Emerging qualitative themes...
原始语种摘要: Germline TP53 mutation carriers are at high risk of developing a range of cancers. Effective cancer risk management is an important issue for these individuals. We assessed the psychosocial impact in TP53 mutation carriers of WB-MRI screening as part of the Surveillance in Multi-Organ Cancer (SMOC+) protocol, measuring their unmet needs, anxiety and depression levels as well as cancer worry using psychological questionnaires and in-depth interviews about their experiences of screening. We present preliminary psychosocial findings from 17 participants during their first 12 months on the trial. We found a significant reduction in participants’ mean anxiety from baseline to two weeks post WB-MRI (1.2, 95% CI 0.17 to 2.23 p = 0.025), indicative of some benefit. Emerging qualitative themes...
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影响因子:1.935 (2012)

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关键词翻译
关键词翻译
  • screening 筛分
  • benefits 津贴费
  • their 他们的
  • support 支柱
  • still 
  • morbidity 病状
  • people 民族
  • abandonment 放弃
  • whole 全部的
  • concern 经济联合体