Estrogen is essential but not sufficient to induce endometriosis
作者: Mosami GalvankarNeha SinghDeepak Modi
作者单位: 1National Institute for Research in Reproductive Health
刊名: Journal of Biosciences, 2017, Vol.42 (2), pp.251-263
来源数据库: Springer Journal
DOI: 10.1007/s12038-017-9687-4
关键词: ApoptosisEndometriosisEstrogenGFPMiceTransplantation
英文摘要: Endometriosis is a common gynaecological disorder of unknown aetiology. Among the several factors, estrogen has been implicated as a causative factor in endometriosis. In the present study using mouse model, we assessed the role of estrogen in the initial implantation and growth of endometrium in ectopic locations. Uterine tissues from green fluorescent protein (GFP) mice were transplanted in to the peritoneum of wild type mice in presence and absence of estrogen. As compared to untreated controls, the implantation of uterine tissue at ectopic locations was higher when estrogen was administered to both host and donor animals. However, this effect was not sustained as lesions regressed within 14 days of treatment. Irrespective of the treatment, peritoneal adipose was the most preferred...
原始语种摘要: Endometriosis is a common gynaecological disorder of unknown aetiology. Among the several factors, estrogen has been implicated as a causative factor in endometriosis. In the present study using mouse model, we assessed the role of estrogen in the initial implantation and growth of endometrium in ectopic locations. Uterine tissues from green fluorescent protein (GFP) mice were transplanted in to the peritoneum of wild type mice in presence and absence of estrogen. As compared to untreated controls, the implantation of uterine tissue at ectopic locations was higher when estrogen was administered to both host and donor animals. However, this effect was not sustained as lesions regressed within 14 days of treatment. Irrespective of the treatment, peritoneal adipose was the most preferred...
全文获取路径: Springer  (合作)
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影响因子:1.759 (2012)

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关键词翻译
关键词翻译
  • endometriosis 子宫内膜异位
  • estrogen 雌激素
  • ectopic 异位的
  • essential 本质的
  • endometrium 子宫内膜
  • sufficient 充分的
  • gynaecological 妇科学的
  • peritoneal 腹膜的
  • sustain 支持
  • irrespective 不考虑的