Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium
作者: Yuan LiuFuai LuLirong KangZhihua WangYongfu Wang
作者单位: 1Inner Mongolia University of Science & Technology
刊名: BMC Pulmonary Medicine, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12890-017-0405-7
关键词: Idiopathic pulmonary fibrosisPirfenidoneOxidative stressNrf2/Bach1
英文摘要: Oxidative stress is one of the important factors involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The equilibrium of Nuclear factor-erythroid-related factor 2 (Nrf2)/[BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap‘n’collar protein) homology 1, Bach1] determines the expression level of antioxidant factors, further regulating the function of oxidation/antioxidation capacity. Pirfenidone (PFD) is one of two currently for IPF therapy approved drugs. PFD regulates intracellular antioxidants, inhibits secretion of inflammatory cytokines and collagen synthesis. However the mechanisms of its antioxidant effects remain elusive.
原始语种摘要: Oxidative stress is one of the important factors involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The equilibrium of Nuclear factor-erythroid-related factor 2 (Nrf2)/[BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap‘n’collar protein) homology 1, Bach1] determines the expression level of antioxidant factors, further regulating the function of oxidation/antioxidation capacity. Pirfenidone (PFD) is one of two currently for IPF therapy approved drugs. PFD regulates intracellular antioxidants, inhibits secretion of inflammatory cytokines and collagen synthesis. However the mechanisms of its antioxidant effects remain elusive.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.76 (2012)

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关键词翻译
关键词翻译
  • fibrosis 纤维化
  • regulating 蝶的
  • bleomycin 博莱霉素
  • pulmonary 肺的
  • antioxidation 抗氧化性
  • antioxidant 抗氧化剂
  • induced 感应的
  • equilibrium 平衡
  • collagen 胶骨硬蛋白质
  • pathogenesis 发病机理