Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation
作者: Zhe ShiHuixia RenZhijian HuangYu PengBaixuan HeXiaoli YaoTi-Fei YuanHuanxing Su
作者单位: 1University of Macau
2Sun Yat-Sen University
3Nanjing Normal University
刊名: Molecular Neurobiology, 2017, Vol.54 (9), pp.7327-7334
来源数据库: Springer Journal
DOI: 10.1007/s12035-016-0212-9
关键词: Fish oilNeuroinflammationDepressionLPSHPA axis
英文摘要: Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil...
原始语种摘要: Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil...
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:5.471 (2012)

×
关键词翻译
关键词翻译
  • LPS Laboratory Peripheral System
  • depressive 降低的
  • hypothalamus 丘脑下部
  • secretion 分泌
  • cytokines 细胞浆移动
  • induced 感应的
  • omega 奥米加
  • Depression 低气压
  • adrenal 肾上腺
  • protect 庇护