Data-Modeling Identifies Conflicting Signaling Axes Governing Myoblast Proliferation and Differentiation Responses to Diverse Ligand Stimuli
作者: Alexander M. LoibenSharon Soueid-BaumgartenRuth F. KopytoDebadrita BhattacharyaJoseph C. KimBenjamin D. Cosgrove
作者单位: 1Cornell University
刊名: Cellular and Molecular Bioengineering, 2017, Vol.10 (5), pp.433-450
来源数据库: Springer Journal
DOI: 10.1007/s12195-017-0508-5
关键词: Cue-signal-response modelingCytokinesGrowth factorsPartial least-squares regressionSkeletal muscleSystems biology
英文摘要: Skeletal muscle tissue development and regeneration relies on the proliferation, maturation and fusion of muscle progenitor cells (myoblasts), which arise transiently from muscle stem cells (satellite cells). Following muscle damage, myoblasts proliferate and differentiate in response to temporally-varying inflammatory cytokines, growth factors, and extracellular matrix cues, which stimulate a shared network of intracellular signaling pathways. Here we present an integrated data-modeling approach to elucidate synergies and antagonisms among proliferation and differentiation signaling axes in myoblasts stimulated by regeneration-associated ligands.
原始语种摘要: Skeletal muscle tissue development and regeneration relies on the proliferation, maturation and fusion of muscle progenitor cells (myoblasts), which arise transiently from muscle stem cells (satellite cells). Following muscle damage, myoblasts proliferate and differentiate in response to temporally-varying inflammatory cytokines, growth factors, and extracellular matrix cues, which stimulate a shared network of intracellular signaling pathways. Here we present an integrated data-modeling approach to elucidate synergies and antagonisms among proliferation and differentiation signaling axes in myoblasts stimulated by regeneration-associated ligands.
全文获取路径: Springer  (合作)
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影响因子:1.443 (2012)

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关键词翻译
关键词翻译
  • muscle 肌肉
  • proliferate 增生
  • regeneration 再生
  • differentiate 微分
  • stimulated 受激
  • cytokines 细胞浆移动
  • cells 麻风细胞
  • signaling 发信号
  • progenitor 祖先
  • modeling 制祝型