Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression
作者: Jenny C. LinkYehudit Hasin-BrumshteinRita M. CantorXuqi ChenArthur P. ArnoldAldons J. LusisKaren Reue
作者单位: 1University of California
刊名: BMC Genomics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12864-017-3484-1
关键词: MicroRNAAdipose tissueSex differencesSex chromosome
英文摘要: MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed at different levels in adipose tissue from lean and obese mice. The degree of lipid accumulation and distribution of white adipose tissue differs between males and females, and it is unknown whether sex differences in adipose tissue-specific miRNA expression may contribute to this dimorphism. Typically, sex differences are attributed to hormones secreted from ovaries or testes. However, the sex chromosome complement (XX versus XY) is also a determinant of sex differences and may regulate miRNA expression in adipocytes.
原始语种摘要: MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed at different levels in adipose tissue from lean and obese mice. The degree of lipid accumulation and distribution of white adipose tissue differs between males and females, and it is unknown whether sex differences in adipose tissue-specific miRNA expression may contribute to this dimorphism. Typically, sex differences are attributed to hormones secreted from ovaries or testes. However, the sex chromosome complement (XX versus XY) is also a determinant of sex differences and may regulate miRNA expression in adipocytes.
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影响因子:4.397 (2012)

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关键词翻译
关键词翻译
  • expression 表示
  • gonadal sex 性腺性别
  • tissue 组织
  • adipose 脂肪的
  • chromosome 染色体
  • interfering 干涉
  • white 白色
  • expressed 榨出的
  • targeting 导向目标
  • regulate 控制