Alterations in Docosahexaenoic Acid-Related Lipid Cascades in Inflammatory Bowel Disease Model Mice
作者: Shin NishiumiYoshihiro IzumiMasaru Yoshida
作者单位: 1Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine
2Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University
3Division of Metabolomics Research, Department of Internal Related, Kobe University Graduate School of Medicine
刊名: Digestive Diseases and Sciences, 2018, Vol.63 (6), pp.1485-1496
来源数据库: Springer Nature Journal
DOI: 10.1007/s10620-018-5025-4
关键词: IBDIL-10 knockout miceMetabolite profilingMass spectrometry
英文摘要: Abstract(#br) Background(#br)Inflammatory bowel disease (IBD) is an intestinal disorder, involving chronic and relapsing inflammation of the digestive tract. Dysregulation of the immune system based on genetic, environmental, and other factors seems to be involved in the onset of IBD, but its exact pathogenesis remains unclear. Therefore, radical treatments for ulcerative colitis and Crohn’s disease remain to be found, and IBD is considered to be a refractory disease.(#br) Aims(#br)The aim of this study is to obtain novel insights into IBD via metabolite profiling of interleukin (IL)-10 knockout mice (an IBD animal model that exhibits a dysregulated immune system).(#br) Methods(#br)In this study, the metabolites in the large intestine and plasma of IL-10 knockout mice were analyzed. In...
全文获取路径: Springer Nature  (合作)
影响因子:2.26 (2012)