Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line
作者: Li-Hsuan HuangHsin-Yun ChungHui-Min Su
作者单位: 1College of Medicine, National Taiwan University
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-017-3936-7
关键词: Fatty acidsDocosahexaenoic acidArachidonic acidFatty acid synthaseEstrogenInsulinPAKT signalingMTORProliferationBreast cancer
英文摘要: Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver. We previously found a positive association between rat mammary tumor levels of the n-6 PUFA arachidonic acid (AA) and tumor weight. We examined the roles of the major n-3 PUFA, docosahexaenoic acid (DHA, 22:6n-3), and the major n-6 PUFA, AA, in FASN expression in, and proliferation of, human breast cancer MCF-7 cells.
原始语种摘要: Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver. We previously found a positive association between rat mammary tumor levels of the n-6 PUFA arachidonic acid (AA) and tumor weight. We examined the roles of the major n-3 PUFA, docosahexaenoic acid (DHA, 22:6n-3), and the major n-6 PUFA, AA, in FASN expression in, and proliferation of, human breast cancer MCF-7 cells.
全文获取路径: Springer  (合作)
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影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • synthase 合酶
  • fatty 脂肪的
  • expression 表示
  • breast 胸部
  • binding 装订
  • major 知的
  • sterol 甾醇
  • cancer 癌症
  • inhibiting 抑制
  • expressed 榨出的