Serum microRNA profiling in patients with glioblastoma: a survival analysis
作者: Hua ZhaoJie ShenTiffany R. HodgesRenduo SongGregory N. FullerAmy B. Heimberger
作者单位: 1The University of Texas MD Anderson Cancer Center
刊名: Molecular Cancer, 2017, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12943-017-0628-5
关键词: Serum microRNAsGlioblastomaAnd prognosis
英文摘要: Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 primary glioblastoma patients. The study subjects were randomly divided into two sets: set one ( n = 40) and set two ( n = 66). Using a Cox regression model, 3 serum miRNAs (miR-106a-5p, miR-182, and miR-145-5p) and 5 serum miRNAs (miR-222-3p, miR-182, miR-20a-5p, miR-106a-5p, and miR-145-5p) were identified significantly associated with 2-year patient overall survival and disease-free survival ( P < 0.05) in both sets and the combined set. We then created the miRNA risk scores to...
原始语种摘要: Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 primary glioblastoma patients. The study subjects were randomly divided into two sets: set one ( n = 40) and set two ( n = 66). Using a Cox regression model, 3 serum miRNAs (miR-106a-5p, miR-182, and miR-145-5p) and 5 serum miRNAs (miR-222-3p, miR-182, miR-20a-5p, miR-106a-5p, and miR-145-5p) were identified significantly associated with 2-year patient overall survival and disease-free survival ( P < 0.05) in both sets and the combined set. We then created the miRNA risk scores to...
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影响因子:5.134 (2012)

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关键词翻译
关键词翻译
  • survival 生存
  • glioblastoma 成胶质细胞瘤
  • profiling 仿形切削
  • serum 血清
  • prognosis 预报
  • significantly 较大地
  • prognostic 预测的
  • combined 组合
  • associated 相关的
  • outcome 效果