Surface-enhanced Raman scattering nanosensors for in vivo detection of nucleic acid targets in a large animal model
作者: Hsin-Neng WangJanna K. RegisterAndrew M. FalesNaveen GandraEugenia H. ChoAlina BoicoGregory M. PalmerBruce KlitzmanTuan Vo-Dinh
作者单位: 1Departments of Biomedical Engineering, Duke University
2Fitzpatrick Institute for Photonics, Duke University
3Medical Center, Duke University
4Departments of Chemistry, Duke University
刊名: Nano Research, 2018, Vol.11 (8), pp.4005-4016
来源数据库: Springer Journal
DOI: 10.1007/s12274-018-1982-3
关键词: NanosensorNanoprobesPlasmonicsNanostarSurface-enhanced Raman scattering (SERS)In vivo sensing
英文摘要: Abstract(#br)Although nanotechnology has led to important advances in in vitro diagnostics, the development of nanosensors for in vivo detection remains very challenging. Here, we demonstrated the proof-of-principle of in vivo detection of nucleic acid targets using a promising type of surface-enhanced Raman scattering (SERS) nanosensor implanted in the skin of a large animal model (pig). The in vivo nanosensor used in this study involves the “inverse molecular sentinel” detection scheme using plasmonics-active nanostars, which have tunable absorption bands in the near infrared region of the “tissue optical window”, rendering them efficient as an optical sensing platform for in vivo optical detection. Ex vivo measurements were also performed using human skin grafts to demonstrate the...
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影响因子:7.392 (2012)

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